Servier CDMO has invested $7.5 million in expanded technology including continuous chromatography with simulated moving bed (SMB) and super critical fluid chromatography (SFC) with solvent recycling at its Bolbec site in Normandy.
 
The company anticipates a 50% increase in productivity in addition to the existing configuration of the high-volume batch columns that are used for drug manufacture. The investment will allow the chemical purification of 50kg (kilograms) per day, and the chiral separation of 10kg per day to support clinical trials and market supply upon approvals.

The Bolbec site offers experts in chemical processes and is certified to handle highly potent compounds to occupational exposure band five (OEB 5). Bolbec is a U.S. FDA cGMP site for pharmaceuticals.